The Tau Progression Index (TPI): an individualized, clinically applicable, multimodally‐derived score to predict AD progression
Despite a small sample size, we demonstrate that an imaging index that incorporates baseline Ab, tau, and subject-specific connectivity can accurately predict future accumulation of tau. Validation in a larger cohort is ongoing.
Authors
- Silky Pahlajani (ORCID: https://orcid.org/0000-0002-2510-9649)
- Davangere P. Devanand (ORCID: https://orcid.org/0000-0001-8597-1380)
- Yaakov Stern (ORCID: https://orcid.org/0000-0002-2342-9497)
- Sindy Ozoria
- Tracy Butler (ORCID: https://orcid.org/0000-0003-0130-8122)
- Nancy S. Foldi (ORCID: https://orcid.org/0000-0001-8810-8558)
- Mohammad Khalafi (ORCID: https://orcid.org/0000-0002-9447-5167)
- Qolamreza Razlighi (ORCID: https://orcid.org/0000-0001-9588-8062)
- Christian Habeck
- Peter Chernek
- Jenseric Calimag
- Hengda He
- Bardiya Ghaderi Yazdi
- Seyed Hani Hojjati
- Sonja Blum
- Gloria Chiang
Institutions
- Cornell University (US)
- Columbia University Irving Medical Center (US)
- Weill Cornell Medicine (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101039
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00