Early neural dysfunction in embryos of an autosomal dominant Alzheimer's Disease rat model
Here, we show that the correlations identified in WTe were not detected in ADAD embryos, indicating early connectivity alterations and potentially future synaptic dysfunction. Further analyses should be conducted at advanced gestational days to better understand the effects of ADAD mutations on the interplay between inhibitory neurons and microglia during neurodevelopment.
Authors
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Gabriela Lazzarotto (ORCID: https://orcid.org/0000-0001-8035-3639)
- Giovanna Carello‐Collar (ORCID: https://orcid.org/0000-0003-4644-0151)
- Maria Luiza Fernandes Dahlem
- Débora Guerini de Souza (ORCID: https://orcid.org/0000-0003-2982-4989)
- André Nunes Mensch
- Vanessa Gomes Ramos
- Diogo O. Souza
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106198
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00