Exploring the Impact of the <i>APOE3‐Christchurch</i> Mutation on APOE Biology Using iPSC‐derived Cortical Organoids
Our findings provide novel insights into how the APOE3Ch variant alters APOE biology, revealing differences in mitochondrial function and lipid metabolism. The differential regulation of mitochondrial pathways in APOE3Ch cerebral organoids, along with the enhanced mitochondrial capacity and altered lipid metabolism observed in APOE3Ch astrocytes, highlights the unique properties of this variant. These results offer valuable mechanistic understanding that may inform future therapeutic strategies targeting APOE biology, particularly in the context of AD.
Authors
- Celeste M M. Karch (ORCID: https://orcid.org/0000-0002-6854-5547)
- Paula Rodríguez Martínez
- Takahisa Kanekiyo (ORCID: https://orcid.org/0000-0001-6751-9374)
- Yuka A. Martens (ORCID: https://orcid.org/0000-0002-5194-4269)
- GuoJun Bu
- Julia T.C.W.
- Yasuteru Inoue (ORCID: https://orcid.org/0000-0003-4180-5908)
- Ana‐Caroline Raulin (ORCID: https://orcid.org/0000-0001-5044-9197)
- Hu Wang (ORCID: https://orcid.org/0000-0002-4476-2344)
- A. Crow (ORCID: https://orcid.org/0000-0002-9102-5793)
- Xianlin Han
- Andrew Keaton Gjelsteen
- Jacob Marsh
- Wenyan Lu
Institutions
- Boston University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Washington University in St. Louis (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107229
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00