Novel Acinar Metaplastic States Uncovered in Exocrine Pancreas Disease
Our findings define a conserved program of acinar plasticity across exocrine pancreas diseases. We further link unresolved ADM to immune remodeling during precursor lesion formation and observe the emergence of pancreatic cancer subtypes in early PanIN lesions.
Authors
- Brian M. Wolpin (ORCID: https://orcid.org/0000-0002-0455-1032)
- Katherine J. Aney
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Sahar Nissim (ORCID: https://orcid.org/0000-0002-2303-6415)
- Pal Koak
- Anders W. Ohman
- Woo-Jeong Jeong
- Canh Hiep Nguyen
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber Brigham Cancer Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101717
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00