Exploring a preclinical cognitive marker for Alzheimer's disease in adults with Down syndrome: preliminary evidence from a conjunctive memory binding assessment

These preliminary findings demonstrate initial feasibility and acceptability of dVSTMB for DS populations; however, evidence of difficulty with task instructions for some participants warrants monitoring in larger samples. DS participants' performances across dVSTMB conditions is in keeping with the expected direction. Some participants met BCS cut-off criteria indicative of Alzheimer's disease, highlighting its potential for AD screening in DS populations. The pilot study is on-going, with future work extending to other learning disability populations planned.