Prospective associations of epigenetic age estimators with incident mild cognitive impairment and dementia among older women: The Women's Health Initiative Memory Study

In one of the largest and most comprehensive studies of epigenetic clocks and cognitive outcomes to date, we found that faster biological aging as indicated by two epigenetic age-acceleration estimators--developed to predict mortality (AgeAccelGrim2) and capture multiple organ system functioning (DunedinPACE)--also predicted incident MCI/dementia. These results show that accelerated epigenetic age based on these estimators could help identify older women at risk for MCI/dementia, and provide insight into pathophysiological mechanisms.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_098954
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
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article

Prospective associations of epigenetic age estimators with incident mild cognitive impairment and dementia among older women: The Women's Health Initiative Memory Study

Linda K. McEvoy, Kenneth B. Beckman, Stephen R. Rapp, M E Espeland et al.
Alzheimer s & Dementia
Epigenetics and DNA Methylation
article

Prospective associations of epigenetic age estimators with incident mild cognitive impairment and dementia among older women: The Women's Health Initiative Memory Study

Linda K. McEvoy, Kenneth B. Beckman, Stephen R. Rapp, M E Espeland, Ake Lu, Steve Horvath, Steve Nguyen, Adam Maihofer, Aladdin H. Shadyab, Andrea Z. LaCroix, Susan M. Resnick, Caroline Nievergelt
article en

Abstract

In one of the largest and most comprehensive studies of epigenetic clocks and cognitive outcomes to date, we found that faster biological aging as indicated by two epigenetic age-acceleration estimators--developed to predict mortality (AgeAccelGrim2) and capture multiple organ system functioning (DunedinPACE)--also predicted incident MCI/dementia. These results show that accelerated epigenetic age based on these estimators could help identify older women at risk for MCI/dementia, and provide insight into pathophysiological mechanisms.

Alzheimer s & DementiaVol. 21(S2)
National Institutes of Health (US), University of Minnesota (US), Kaiser Permanente Washington Health Research Institute (US), University of California San Diego (US), Cambridgeshire County Council (GB), National Institute on Aging (US), Wake Forest University (US)
Good health and well-being
Openalex Percentile: Top 36%
Epigenetics and DNA Methylation
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Prospective associations of epigenetic age estimators with incident mild cognitive impairment and dementia among older women: The Women's Health Initiative Memory Study — Linda K. McEvoy, Kenneth B. Beckman, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS