Tau phosphorylation highlight amyloid precursor protein role in Alzheimer’s disease beyond Aβ production

Interactions among GSK-3β, APP and tau contribute to the cytotoxic effects observed in neuronal cells. These mechanisms may involve transcriptional events within the nucleus, ultimately impacting tau phosphorylation. Understanding these intricate pathways is essential for developing targeted therapies to mitigate tau-related neurodegeneration.