Brain structural‐functional coupling is differentially affected by age, sex, and amyloid burden in older individuals without dementia
Our findings demonstrate that age, sex, and global amyloid burden independently and differentially relate to structural-functional coupling across brain scales. This work highlights the sensitivity of multimodal brain network analyses in detecting changes that may reflect distinct pathophysiological processes in aging and early AD.
Authors
- JT Cole
- Mario Tranfa (ORCID: https://orcid.org/0000-0002-4451-4746)
- Lanius
- Prithvi Arunachalam (ORCID: https://orcid.org/0000-0002-0798-6250)
- MM Schoonheim
- Federico Masserini (ORCID: https://orcid.org/0000-0002-0746-7426)
- Linda Douw (ORCID: https://orcid.org/0000-0001-7058-4062)
- Leonard Pieperhoff (ORCID: https://orcid.org/0009-0003-9003-4588)
- Marta Marquié
- Francesca Treves
- Tommy A. A. Broeders
- Mercè Boada
- Pieter Jelle Visser
- Giuseppe Pontillo
- Craig Ritchie
- Juan Domingo Gispert
- Maria G. Preti
- Alle Meije Wink
- Lyduine E. Collij
Institutions
- University of Geneva (CH)
- Lund University (SE)
- University of Milan (IT)
- University of Pavia (IT)
- Karolinska Institutet (SE)
- Universitat Internacional de Catalunya (ES)
- Maastricht University (NL)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- The London College (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Naples Federico II (IT)
- University of Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099673
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00