Small Molecule Targeting of Chaperone {IP Protein} Prevents and Reverses TDP‐43 Aggregation In‐vitro and In‐vivo

We have validated JRMS as a preclinical therapeutic candidate for the treatment of TDP-43 proteinopathy, with additional preliminary evidence for Tauopathies as well. We are currently working on building a Target Product Profile (TPP) with the goal of providing a drug(s) for clinical testing.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_099984
Citations
1
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
1.39
Controls
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article

Small Molecule Targeting of Chaperone {IP Protein} Prevents and Reverses TDP‐43 Aggregation In‐vitro and In‐vivo

Marc Shenouda, Janice Robertson
1 citations
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
1.39
article

Small Molecule Targeting of Chaperone {IP Protein} Prevents and Reverses TDP‐43 Aggregation In‐vitro and In‐vivo

Marc Shenouda, Janice Robertson
article en
1 citations

Abstract

We have validated JRMS as a preclinical therapeutic candidate for the treatment of TDP-43 proteinopathy, with additional preliminary evidence for Tauopathies as well. We are currently working on building a Target Product Profile (TPP) with the goal of providing a drug(s) for clinical testing.

Alzheimer s & DementiaVol. 21(S5)
University of Toronto (CA), Occupational Cancer Research Centre (CA)
Openalex Percentile: Top 13%
Amyotrophic Lateral Sclerosis Research
1.39
DOIOpen Access PDFOpenAlex
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Small Molecule Targeting of Chaperone {IP Protein} Prevents and Reverses TDP‐43 Aggregation In‐vitro and In‐vivo — Marc Shenouda, Janice Robertson · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS