Sensitivity of cognitive composite scores to amyloid accumulation in emergent Alzheimer's disease
In individuals with increasing Aβ levels before meeting the criteria for stage 2 AD, the memory composite showed the greatest sensitivity to Aβ-related cognitive changes. These findings suggest clinical trials for emergent AD should include assessments of memory to capture AD-related cognitive changes.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Yen Ying Lim (ORCID: https://orcid.org/0000-0002-0308-5156)
- Paul T. Maruff (ORCID: https://orcid.org/0000-0002-6947-9537)
- Joanne S. Robertson
- C. Rowe
- Colin L. Masters
- Pierrick Bourgeat
- Ying Xia
- for the AIBL study investigators
- Jurgen Fripp
Institutions
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Australian e-Health Research Centre (AU)
- CSIRO Health and Biosecurity (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100567
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00