Examining White Matter Hyperintensities, Hippocampal Subfields, Cognitive Function, and Plasma Biomarkers in Recovered COVID‐19 Patients
In this multinational 7T MRI cohort, hospitalization for COVID-19 was associated with worse cognitive performance, smaller hippocampal volumes, and distinct relationships between imaging and cognitive markers but not plasma biomarkers, highlighting lasting neurological impacts of severe illness. Longitudinal assessments and the inclusion of other illnesses, such as pneumonia and sepsis, could clarify the impact of COVID-19 hospitalization on overall brain health.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Gabriel de Erausquin
- Monica Goss
- Olivier Mougin (ORCID: https://orcid.org/0000-0001-9675-3530)
- J Li
- Valentina R. Garbarino (ORCID: https://orcid.org/0000-0002-0973-7186)
- Joseph Mettenburg
- Dr.Dharmesh V. Patel
- Akram A. Hosseini (ORCID: https://orcid.org/0000-0003-0133-9842)
- Tiffany F. Kautz (ORCID: https://orcid.org/0000-0001-7680-4708)
- Oluwatobi F Adeyemi (ORCID: https://orcid.org/0000-0001-9415-4112)
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Farhaan Vahidy (ORCID: https://orcid.org/0000-0002-3464-2111)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Peter J. Gianaros (ORCID: https://orcid.org/0000-0003-2313-5277)
- Christof Karmonik (ORCID: https://orcid.org/0000-0002-6695-9535)
- Richard Bowtell (ORCID: https://orcid.org/0000-0001-8656-412X)
- Julie Parker‐Garza
- Minjie Wu (ORCID: https://orcid.org/0000-0002-8978-3851)
- Tamer S. Ibrahim
- Jayandra J. Himali
- Mohammad Zia U.H Katshu
- Penny Gowland
- Tales Santini
- Timothy D. Girard
- Anna Marsland
- Jr‐Jiun Liou
- Mohamad Habes
- Sudha Seshadri
Institutions
- Houston Methodist (US)
- University of Nottingham (GB)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- Massachusetts General Hospital (US)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098083
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00