Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature
SLE pregnancies are characterized by a failure to achieve monocyte immunotolerance, driven in part by aberrant miRNA regulation. These findings highlight molecular mechanisms underlying persistent inflammation in SLE pregnancy and identify candidate transcriptomic and miRNA biomarkers that may support future risk stratification or therapeutic modulation.
Authors
- Eloi Schmauch (ORCID: https://orcid.org/0000-0002-2123-8777)
- Philippe Georgel (ORCID: https://orcid.org/0000-0001-6853-7080)
- Nicodème Paul
- Seiamak Bahram (ORCID: https://orcid.org/0000-0002-6928-9952)
- C. Schmidt-Mutter
- Angélique Pichot
- Ghada Alsaleh (ORCID: https://orcid.org/0000-0002-4211-3420)
- Raphaël Carapito (ORCID: https://orcid.org/0000-0002-7036-442X)
- Anne Molitor (ORCID: https://orcid.org/0000-0003-1646-2325)
- François Lefebvre (ORCID: https://orcid.org/0000-0002-1105-8289)
- Jean Sibilia
- Marc Scherlinger
Institutions
- Inserm (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Biotechnologie et Signalisation Cellulaire (FR)
- Hôpital Civil, Strasbourg (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100347
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00