Higher off‐target meninges [F‐18]MK6240 PET signal associated with APOE4 carriage
Spill-in effects from MK6240 meninges signal can potentially bias tracer outcomes in target analysis regions. Meninges signal can be highly variable, but the relationships between APOE4 carriage and sex on this measure should be accounted for in MK6240 quantification and population-based comparisons.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Brecca Bettcher
- Andrew K McVea (ORCID: https://orcid.org/0009-0008-4525-2793)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Max McLachlan (ORCID: https://orcid.org/0000-0003-1801-7233)
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Bradley T Christian
- Susan M. Landau
- Sterling C Johnson
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- Wisconsin Division of Public Health (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099910
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00