Evaluation of the revised criteria for biological and clinical staging of Alzheimer's disease
In this study we validated the new AD staging criteria and found that co-pathologies play an important role in symptom severity in individuals harboring less tau tangle pathology than expected for their clinical impairment. These results highlight the importance of measuring non-AD biomarkers in patients with worse cognitive impairment than expected based on their biological stage, which could impact clinical diagnosis and prognosis.
Authors
- Piero Parchi (ORCID: https://orcid.org/0000-0002-9444-9524)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Pontus Tideman (ORCID: https://orcid.org/0000-0002-9620-7115)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Danielle van Westen (ORCID: https://orcid.org/0000-0001-8649-9874)
- Kaj Blennow
- Colin Groot (ORCID: https://orcid.org/0000-0002-4384-0160)
- Oskar H. Hansson
- Alexa Pichet Binette
- Henrik Zetterberg
- Sebastian Palmqvist
- Isabelle Glans
- Niklas Mattsson‐Carlgren
- Shorena Janelidze
- Ruben Smith
Institutions
- University of Wisconsin–Madison (US)
- Lund University (SE)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Profu (Sweden) (SE)
- Pasqual Maragall Foundation (ES)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Barcelonaβeta Brain Research Center (ES)
- Skåne University Hospital (SE)
- Wisconsin Division of Public Health (US)
- Amsterdam University Medical Centers (NL)
- Institut du Cerveau (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University College London (GB)
- Université de Montréal (CA)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Bologna (IT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098208
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00