Neuroprotective potential of 17‐beta Estradiol: Targeting Inflammation and Mitochondrial Dysfunction in Alzheimer’s Disease

Our findings so far demonstrate that E2 exerts significant neuroprotective effects against Aβ in primary cortical neurons. E2 effectively mitigates Aβ-mediated mitochondrial dysfunction, inflammation, and neurotoxicity by restoring key regulatory proteins, reducing inflammatory markers and, enhancing mitochondrial function. These findings suggest that E2 could potentially serve as a therapeutic agent against AD, addressing both mitochondrial dysfunction and neuroinflammation.