Amygdala nuclei are not uniformly vulnerable to FTLD‐tauopathies in PPA
Findings highlight distinct vulnerabilities of amygdala nuclei in PPA due to FTLD-tauopathies. Irrespective of tauopathy, the basal nucleus showed the greatest neuronal loss and tau pathology in PPA. PPA/3R showed more global tau accumulation and lateral nucleus neuronal loss, whereas PPA/4R demonstrated greater central nucleus glial tau accumulation. Results also demonstrate leftward asymmetry of pathogenesis in PPA, even in limbic regions. Future investigation of neuroinflammation and synaptic markers may yield additional insights into these vulnerabilities.
Authors
- Tamar Gefen (ORCID: https://orcid.org/0000-0002-2380-3100)
- Marek M. Mesulam
- Rachel Keszycki (ORCID: https://orcid.org/0000-0001-7686-2959)
- Antonia Zouridakis (ORCID: https://orcid.org/0000-0002-6404-3558)
- Allegra Kawles (ORCID: https://orcid.org/0000-0003-3153-5350)
- Grace Minogue (ORCID: https://orcid.org/0000-0002-1324-1351)
- Sandra Weintraub
- Ivan Ayala
- Caroline M Nelson
- Changiz Geula
- Rudolph J Castellani
- Alyssa Macomber
Institutions
- Northwestern University (US)
- Brown University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107447
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 0.00