Causal Network of TRIM11: Exploring Druggable Pathways in Alzheimer's Disease
By integrating Pearson correlation analysis, Bayesian framework, and NOTEARS causal network modeling, we identified key genes that may influence TRIM11 expression. Future studies can focus on experimental validation of these genes and exploring their functional roles in pathways associated with TRIM11 to uncover potential therapeutic targets.
Authors
- Li Shen (ORCID: https://orcid.org/0000-0002-5190-2851)
- Sumita Garai (ORCID: https://orcid.org/0000-0001-6035-4837)
- Alvin Pham
- Tianhua Zhai
Institutions
- University of Pennsylvania (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106783
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00