Neuropsychological and neuroimaging preliminary results supporting prodromal dementia with Lewy bodies criteria

In line with the full-blown disease, the neuropsychological profile of pro-DLB patients is characterized by deficits in visuo-perceptive, visuo-spatial and visuo-constructive abilities as well as executive functions and attention. Accordingly, the neuropsychological assessment should focus on the evaluation of these cognitive domains employing the most sensitive tests (including computerized ones). Notably, the localization of brain atrophy is coherent not only with neuropsychological deficits and neuropsychiatric symptoms, but also with the different phenotypes of pro-DLB.