White Matter Hyperintensities burden is associated with higher plasma NfL and poorer global cognition in MCI: Findings from the Southeast Asian BIOCIS study
NfL, a neurodegenerative measure is increased in a younger Southeast Asian community MCI population with high WMH burden. A plateau of this increase is observed in the older MCI population, which could be a result of threshold effects together with reduced neurobiological capacity. This makes NfL a promising biomarker for the early detection and prognostication of white matter disease and resultant cognitive impairment among Southeast Asians, allowing for the application of beneficial and timely interventions. Further mechanistic validation in a larger more pathologically stratified cohort, followed by longitudinal follow-up is underway.
Authors
- Jacklyn Leonardo (ORCID: https://orcid.org/0000-0003-0878-8149)
- Ashwati Vipin (ORCID: https://orcid.org/0000-0002-3575-7287)
- Gurveen Kaur Sandhu
- Gaurav Bhalla (ORCID: https://orcid.org/0000-0003-0337-3809)
- Kiirtaara Aravindhan (ORCID: https://orcid.org/0000-0002-8941-1679)
- Smriti Ghildiyal (ORCID: https://orcid.org/0009-0007-7765-3551)
- Pricilia Tanoto (ORCID: https://orcid.org/0009-0002-5456-690X)
- Nagaendran Kandiah
- Bocheng Qiu (ORCID: https://orcid.org/0009-0005-3255-7027)
- Reza Salim
- Shan Yao Liew
- Xin Ying Sim
- Fatin Zahra Zailan
- Faith Phemie Hui En Lee
- Yi Jin Leow
Institutions
- Nanyang Technological University (SG)
- NIL Technology (Denmark) (DK)
- Singapore Centre for Environmental Life Sciences Engineering (SG)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101548
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00