Unveiling the Possible Role of Neuroprotective Efficacy of Hordenine (HOR) Barley Derived Natural Product Against Scopolamine Induced Alzheimer's Disease & Neurotoxicity in Experimental Rats
Hordenine administration resulted in significant improvements in memory and cognitive function, thereby demonstrating a pronounced neuroprotective effect against scopolamine-induced Alzheimer's disease. These findings suggest that hordenine may exert its therapeutic action by attenuating oxidative stress and neuroinflammation, thereby mitigating cognitive decline. Furthermore, hordenine appears to preserve the integrity of the brain's histological structure, offering potential as a candidate for reversing neurodegenerative processes associated with Alzheimer's disease.
Authors
- Manmohan Singhal
- Mohit Agrawal (ORCID: https://orcid.org/0000-0003-0200-7882)
Institutions
- KR Mangalam University (IN)
- Dehradun Institute of Technology University (IN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_098761
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00