Unveiling the Possible Role of Neuroprotective Efficacy of Hordenine (HOR) Barley Derived Natural Product Against Scopolamine Induced Alzheimer's Disease & Neurotoxicity in Experimental Rats

Hordenine administration resulted in significant improvements in memory and cognitive function, thereby demonstrating a pronounced neuroprotective effect against scopolamine-induced Alzheimer's disease. These findings suggest that hordenine may exert its therapeutic action by attenuating oxidative stress and neuroinflammation, thereby mitigating cognitive decline. Furthermore, hordenine appears to preserve the integrity of the brain's histological structure, offering potential as a candidate for reversing neurodegenerative processes associated with Alzheimer's disease.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_098761
Primary Topic
Berberine and alkaloids research
Type
article
Field-Weighted Citation Impact
0.00
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article

Unveiling the Possible Role of Neuroprotective Efficacy of Hordenine (HOR) Barley Derived Natural Product Against Scopolamine Induced Alzheimer's Disease & Neurotoxicity in Experimental Rats

Manmohan Singhal, Mohit Agrawal
Alzheimer s & Dementia
Berberine and alkaloids research
article

Unveiling the Possible Role of Neuroprotective Efficacy of Hordenine (HOR) Barley Derived Natural Product Against Scopolamine Induced Alzheimer's Disease & Neurotoxicity in Experimental Rats

Manmohan Singhal, Mohit Agrawal
article en

Abstract

Hordenine administration resulted in significant improvements in memory and cognitive function, thereby demonstrating a pronounced neuroprotective effect against scopolamine-induced Alzheimer's disease. These findings suggest that hordenine may exert its therapeutic action by attenuating oxidative stress and neuroinflammation, thereby mitigating cognitive decline. Furthermore, hordenine appears to preserve the integrity of the brain's histological structure, offering potential as a candidate for reversing neurodegenerative processes associated with Alzheimer's disease.

Alzheimer s & DementiaVol. 21(S5)
KR Mangalam University (IN), Dehradun Institute of Technology University (IN)
Openalex Percentile: Top 30%
Berberine and alkaloids research
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