Limbic‐predominant age‐related TDP‐43 encephalopathy, but Not Alzheimer's Disease, neuropathological changes are associated with Physical Performance Decline in the Oldest Old: Insights from The 90+ Study

LATE, but not AD, neuropathological changes are significantly associated with faster decline in physical performance in the oldest old. These findings indicate that, despite the similar cognitive presentations of LATE and AD, the physical manifestations of these neuropathological changes may be different. Further research into physical performance as a potential marker of LATE-NC could improve our ability to distinguish between these neuropathological changes during life.