MiR-668-3p in M2 macrophage-derived exosomes activates autophagy through the ETS1/EGFR axis and promotes cisplatin resistance in gastric cancer
M2 macrophage-derived exosomal miR-668-3p promotes DDP resistance in GC cells by targeting the ETS1/EGFR axis, thereby activating the autophagy pathway. Future research should focus on developing targeted inhibition strategies for miR-668-3p to effectively reverse DDP resistance in GC cells, optimizing its potential for clinical application.
Authors
- Zunqi Hu
- Zhenxin Zhu (ORCID: https://orcid.org/0000-0003-4622-6446)
- Dejun Yang
- Hongbing Fu
- Weijun Wang
- Dapeng Xu
- Zhi Zheng
- Ziran Wei
- Ronglin Yan
- Xin Huang
- Xin Zhang
Institutions
- Renji Hospital (CN)
- Jiading District Central Hospital (CN)
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1186/s12935-025-04140-y
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00