Portable Low‐Field MRI for Rapid Detection and Monitoring of ARIA in Lecanemab‐Treated Alzheimer's Disease Patients: A Pilot Study

This pilot study suggests that portable LF MRI can detect and monitor ARIA-E in patients treated with lecanemab, potentially circumventing delays associated with HF MRI. Although image quality is lower than HF MRI, the ability to guide therapeutic decisions promptly may prove clinically significant. Further larger-scale studies are warranted to validate these initial findings, refine imaging protocols, and explore the broader role of LF MRI in routine ARIA screening and follow-up.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_100090
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

Portable Low‐Field MRI for Rapid Detection and Monitoring of ARIA in Lecanemab‐Treated Alzheimer's Disease Patients: A Pilot Study

Shenghua Zhu, Jarrel Seah, Saurabh Rohatgi, Javier Romero et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Portable Low‐Field MRI for Rapid Detection and Monitoring of ARIA in Lecanemab‐Treated Alzheimer's Disease Patients: A Pilot Study

Shenghua Zhu, Jarrel Seah, Saurabh Rohatgi, Javier Romero, John C. Ford, Esteban Calle Cadavid
article en

Abstract

This pilot study suggests that portable LF MRI can detect and monitor ARIA-E in patients treated with lecanemab, potentially circumventing delays associated with HF MRI. Although image quality is lower than HF MRI, the ability to guide therapeutic decisions promptly may prove clinically significant. Further larger-scale studies are warranted to validate these initial findings, refine imaging protocols, and explore the broader role of LF MRI in routine ARIA screening and follow-up.

Alzheimer s & DementiaVol. 21(S3)
Massachusetts General Hospital (US)
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
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