Improving Genotype Imputation of African‐derived Genetic Variants in Studies of Alzheimer's Disease
The use of meta-imputation to better match the genetic background of the DAWN dataset through the use of multiple imputation references significantly increases the density and quality of the resulting genotypic dataset, enabling more powerful studies of AD genetics. This demonstrates the utility of meta-imputation for better matching the genetic background of samples when performing imputation.
Authors
- Patrice Whitehead
- Joshua Odunayo Akinyemi (ORCID: https://orcid.org/0000-0002-0675-2110)
- Mayowa Ogunronbi (ORCID: https://orcid.org/0000-0003-4104-2728)
- Blanton Susan
- Kazeem Abiodun Akinwande (ORCID: https://orcid.org/0000-0003-0302-1598)
- Reginald Obiako (ORCID: https://orcid.org/0000-0003-1769-8110)
- Albert Akpalu (ORCID: https://orcid.org/0000-0002-4802-9852)
- Yared Z. Zewde (ORCID: https://orcid.org/0000-0002-6442-7148)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- D. M. Ndetei
- Biniyam Ayele
- Raj N Kalaria
- OO Baiyewu
- Bush Wh
- Adam C Naj
- Izri M Martinez
- Giuseppe Tosto
- Margaret Pericak‐Vance
- Samuel Diala
- Rufus O. Akinyemi
- Katalina F. McInerney
- Anthony J Griswold
- Kara L Hamilton‐Nelson
- Fred Stephen Sarfo
- Allison M Caban‐Holt
- Jonathan L Haines
- Nicholas R. Wheeler
- Kyle M Scott
- Christiane Reitz
- Andrew F Zaman
- Njideka U Okubadejo
- Larry D Adams
- Farid Rajabli
- Michael L Cuccaro
- Goldie S Byrd
- Adesola Ogunniyi
- Brian W Kunkle
- Albertino Damasceno
- Jeffery M Vance
- Kolawole Wahab
- Mayowa O Owolabi
- Motunrayo Coker
Institutions
- Ahmadu Bello University (NG)
- University of Ilorin (NG)
- University of Ghana (GH)
- University of Miami (US)
- Eduardo Mondlane University (MZ)
- University of Ibadan (NG)
- University of Lagos (NG)
- Komfo Anokye Teaching Hospital (GH)
- Ahmadu Bello University Teaching Hospital (NG)
- Dr. John T. Macdonald Foundation (US)
- University School (US)
- Addis Ababa University (ET)
- Wake Forest University (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Newcastle University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106790
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00