Down Syndrome and Alzheimer's Disease in a Dish: A multidimensional front‐door spanning pathogenesis and therapeutics

The iPSC panel provides valuable insights into AD, DS, and related systems by distinguishing gene influences. Integration of 14 multidimensional datasets-spanning behavioral, cognitive, and neural imaging data-offers a detailed view of brain function, behavior, and organ development. This comprehensive approach allows for the dissection of AD and DS pathogenesis and the modeling of multiple human organs and cell types CONCLUSION: This work creates a comprehensive resource to understand DS at the organismal, cellular, and systems levels. The Utah iPSC collection is an invaluable tool for accelerating research translation into therapeutic strategies to improve the quality of life for individuals with DS and related conditions.