Proteomic profiling of Tau interactome in brain‐derived extracellular vesicles uncover key molecules contributing to tau pathology spread in Alzheimer's disease
Our study identified tau-interacting molecules highly enriched in AD BDEVs compared to CTRL BDVs. Silencing of candidate molecule reduced tau loading to the EVs and their uptake by iNeurons and neutralizing antibody suppressed tau dissemination, highlighting them as promising therapeutic targets to halt tau pathology in AD and related tauopathy.
Authors
- Tsuneya Ikezu (ORCID: https://orcid.org/0000-0002-3979-8596)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Michael DeTure (ORCID: https://orcid.org/0000-0002-4363-1262)
- Ziteng Zhang
- Seiko Ikezu (ORCID: https://orcid.org/0000-0001-9879-730X)
- Junmin Peng
- Bridgette Melvin
- Alejandro Longtree‐Preciado
- Arun Reddy Ravula
- Yunfei I Chen
- Yang You
- Kaiwen Yu
Institutions
- St. Jude Children's Research Hospital (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107077
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00