Sex‐specific associations between blood pressure and white matter hyperintensity accumulation in functionally intact older adults
Functionally intact females show greater WMH accumulation over time compared to males. However, systolic BP was a significant predictor of WMH burden in males only, suggesting other factors may contribute to female WMH burden. While higher systolic BP associated with GMV loss over time, sex differences appeared specific to WMH. These findings underscore the importance of considering sex-specific mechanisms of vascular contributions to brain aging.
Authors
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- Molly Memel (ORCID: https://orcid.org/0000-0001-6827-6335)
- Claire J. Cadwallader (ORCID: https://orcid.org/0000-0003-3449-3803)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Coty Chen
- Molly Olzinski
- Rowan Saloner
- Kaitlin B Casaletto
- Joel H Kramer
- Valentina E. Diaz
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101229
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00