The association of glycemic dysregulation with cognitive decline and structural MRI brain volumes in The Maastricht Study – A role for peripheral inflammation?
Together, our findings suggest that glycemic dysregulation and peripheral inflammation are independently associated with cognitive decline and structural MRI brain volumes. Additionally, persons with lower inflammation might be more vulnerable to cognitive decline through glycemic dysregulation. This emphasizes the importance of targeting both glucose control and inflammation to slow cognitive decline in individuals with glycemic dysregulation.
Authors
- W.H. Backes
- Berendschot TT
- Jacobus F.A. Jansen (ORCID: https://orcid.org/0000-0002-5271-8060)
- Giuseppe Nicolò Fanelli (ORCID: https://orcid.org/0000-0001-7069-7980)
- N. Roth Mota
- Carla Kallen (ORCID: https://orcid.org/0000-0003-1468-8793)
- Veerle van Gils (ORCID: https://orcid.org/0000-0001-8240-5367)
- S. Jasmijn Vos (ORCID: https://orcid.org/0000-0003-3102-514X)
- Gabriëlla A.M. Blokland
- Annemarie Koster
- Jordi Salas Salvadó
- David E.J. Linden
- Søren Dalsgaard
- Willemijn J Jansen
- Anke Wesselius
- Carlos Gómez‐Martínez
- Kay Deckers
- Miranda T. Schram
- Pieter Jelle Visser
- Sebastian Köhler
- Marleen M.J. van Greevenbroek
Institutions
- University of Copenhagen (DK)
- Radboud University Nijmegen (NL)
- Transnational University Limburg (NL)
- Mental Health Services (DK)
- Instituto de Salud Carlos III (ES)
- Copenhagen University Hospital (DK)
- Radboud University Medical Center (NL)
- Aarhus Business College (DK)
- Maastricht University (NL)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Amsterdam Neuroscience (NL)
- Department of Health (TW)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_100484
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00