CSF and plasma proteomic insights into the pathophysiology of cerebral small vessel disease and cerebrovascular event risk prediction
Our findings reveal proteins linked to WML progression and cognitive decline, advancing the understanding of cSVD pathophysiology. Validation of key proteomic markers in plasma and demonstration of their predictive value for cerebrovascular outcomes highlight their potential for early risk stratification and personalized prevention.
Authors
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Atul Kumar (ORCID: https://orcid.org/0009-0000-0804-548X)
- Olof T. Strandberg
- Inès Hristovska (ORCID: https://orcid.org/0000-0003-4779-4103)
- Lena Karlsson (ORCID: https://orcid.org/0000-0003-2749-7195)
- Danielle van Westen (ORCID: https://orcid.org/0000-0001-8649-9874)
- Malin Wennström (ORCID: https://orcid.org/0000-0002-9957-1801)
- Oskar H. Hansson
- Alexa Pichet Binette
- Chris Gaiteri
- Niklas Mattsson‐Carlgren
- Sebastian Palmqvist
- Shorena Janelidze
- Jacob W. Vogel
Institutions
- Rush University Medical Center (US)
- Malmö University (SE)
- Lund University (SE)
- SUNY Upstate Medical University (US)
- Science for Life Laboratory (SE)
- Amsterdam Neuroscience (NL)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Skåne University Hospital (SE)
- Amsterdam University Medical Centers (NL)
- Université de Montréal (CA)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098830
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00