Microglial MS4A4A elevates TREM2 signaling and reduces amyloid pathology

Our findings underscore the critical role of MS4A4A in modulating AD pathology through TREM2. These results position MS4A4A as a promising therapeutic target for AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_106607
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Microglial MS4A4A elevates TREM2 signaling and reduces amyloid pathology

Hengjun Rao, Xiao‐Fen Chen
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

Microglial MS4A4A elevates TREM2 signaling and reduces amyloid pathology

Hengjun Rao, Xiao‐Fen Chen
article en

Abstract

Our findings underscore the critical role of MS4A4A in modulating AD pathology through TREM2. These results position MS4A4A as a promising therapeutic target for AD.

Alzheimer s & DementiaVol. 21(S1)
Xiamen University (CN)
Openalex Percentile: Top 38%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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Microglial MS4A4A elevates TREM2 signaling and reduces amyloid pathology — Hengjun Rao, Xiao‐Fen Chen · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS