YK-4-279 Induces Osteosarcoma Cell Cycle Arrest, DNA Damage Response, and Apoptosis by Regulating the MAPK Cascade
YK-4-279 inhibits OS cell growth, induces DNA damage and cell cycle arrest, and promotes apoptosis via MAPK pathway activation. These findings highlight its strong therapeutic potential for OS treatment.
Authors
- Liren Han (ORCID: https://orcid.org/0000-0003-4400-3388)
- Xiuqin Jia
- Ming Xin
- Weifeng Wang
- Yuli Zhang
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Liaocheng People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s542983
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.00