Amyloid‐induced neuronal hyperactivity and ‐metabolism are associated with faster tau accumulation in Alzheimer's Disease
Aβ promotes an hyper-excitatory shift in neuronal activity that manifests in glucose hypermetabolism which promotes Aβ-related tau accumulation. Thus, Aβ-associated neuronal hyper-excitability is a potential target for attenuating the Ab-tau axis in AD.
Authors
- Maura Malpetti (ORCID: https://orcid.org/0000-0001-8923-9656)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Johannes Gnörich (ORCID: https://orcid.org/0000-0003-1554-7765)
- M Dichgans
- Fabian Hirsch (ORCID: https://orcid.org/0000-0002-5370-4031)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Davina Biel (ORCID: https://orcid.org/0000-0002-2597-1992)
- Shaoshi Zhang (ORCID: https://orcid.org/0000-0001-7791-8774)
- Thomas Yeo
- Lisa Evangelista
- Sebastian N. Roemer‐Cassiano
- Julia Pescoller
- Zeyu Zhu
- Anna Dewenter
- Lukas Frontzkowski
- Madleen Klonowksi
- Sarah Jäkel
- Günter U Höglinger
- Matthias Brendel
Institutions
- National University of Singapore (SG)
- University of Cambridge (GB)
- German Center for Neurodegenerative Diseases (DE)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- München Klinik (DE)
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Imperial College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
- University of Sheffield (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099685
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00