Ancestry‐informed fine‐mapping and sequence analysis of the <i>BIN1</i> locus pinpoints rs6733839 as a causative variant shared between individuals of European and African ancestry with non‐Mendelian early‐onset Alzheimer's Disease

Multi-ancestry fine-mapping pinpoints rs6733839 as a likely causative variant associated with non-Mendelian EOAD and suggests that it is shared across individuals of European and African ancestry. These findings elucidate the etiology of this type of AD in these populations and demonstrate the value of ancestry-informed fine-mapping for identification of population-specific causative variants.