3D bioprinted skin constructs for dermatologic disease: A systematic review

3D bioprinting is an emerging tissue engineering technology that uses computer-aided design and layer-bylayer fabrication to create personalized artificial skin with vascularization and cellular complexity that enhance physiologic relevance. 1It has been widely studied in regenerative and reconstructive surgery as an alternative to grafting for acute wound repair and burn reconstruction, demonstrating successful generation of functional skin constructs. 2-4However, despite these advances in surgical contexts, its application to chronic dermatologic disease remains limited.Most studies in this area focus on disease modeling to investigate pathologic skin mechanisms rather than therapeutic use, though early preclinical work by N ornberg et al suggests potential treatment applications. 1,5 systematic search of PubMed, Embase, and Cochrane Library databases was performed in accordance with PRISMA guidelines.The search included English-language articles published between January 1, 2005, and June 13, 2025 (see Supplementary Appendix, available via Mendeley at 10.17632/ vr9kk7k8y3.1).A total of 558 articles were identified, of which 6 met inclusion criteria.These studies used 3D bioprinting to develop skin models for chronic dermatological diseases, with 3(50%) focusing on atopic dermatitis, and others addressing psoriasis and pemphigus vulgaris.