GWAS of 205,500 Alzheimer's disease and related dementia cases reveals 19 novel, European specific and 11 cross‐ancestry risk loci

The MVP-specific genes may be involved in processes related to more general (not AD specific) dementia pathways or have stronger effects in males. Several of the novel genes identified in EUR and cross-ancestry meta-analysis are involved in neuronal development and function or have been linked to cognitive outcomes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105500
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

GWAS of 205,500 Alzheimer's disease and related dementia cases reveals 19 novel, European specific and 11 cross‐ancestry risk loci

VA Million Veteran Program, Lindsay AA. Farrer, Henry Bayly, Matthew S. Panizzon et al.
Alzheimer s & Dementia
Genetic Associations and Epidemiology
article

GWAS of 205,500 Alzheimer's disease and related dementia cases reveals 19 novel, European specific and 11 cross‐ancestry risk loci

VA Million Veteran Program, Lindsay AA. Farrer, Henry Bayly, Matthew S. Panizzon, Victoria C. Merritt, Rui Zhang, Mark W. Logue, Richard Sherva, Richard L. Hauger, Jesse Mez, J. Michael Gaziano
article en

Abstract

The MVP-specific genes may be involved in processes related to more general (not AD specific) dementia pathways or have stronger effects in males. Several of the novel genes identified in EUR and cross-ancestry meta-analysis are involved in neuronal development and function or have been linked to cognitive outcomes.

Alzheimer s & DementiaVol. 21(S1)
Boston University (US), Brigham and Women's Hospital (US), VA Boston Healthcare System (US), University of California San Diego (US), VA San Diego Healthcare System (US), National Center for PTSD (US), Framingham Heart Study (US)
Openalex Percentile: Top 25%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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