Investigating GDS and its symptoms with ATN biomarkers in diverse populations

Our findings demonstrate significant associations between depression, AD diagnosis, and key plasma biomarkers of neurodegeneration. The strong relationship between recent depression and AD diagnosis, along with the correlations between GDS-30 scores and plasma biomarkers (GFAP, tau, and NfL), suggests potential shared neurobiological mechanisms between depression and AD pathology. To further validate these findings and explore potential demographic influences, we will present results from an additional independent cohort and conduct stratified analyses across sex and ethnic groups.