Effects of Icosapent Ethyl, <i>APOE</i> Genotype and CSF Biomarkers on 4D Flow MRI Metrics of Vascular Health in Cognitively Unimpaired Veterans

IPE treatment did not significantly impact PCVIPR measures of cerebral blood flow. Baseline vascular CSF biomarker levels, but not APOE ε4 carrier status, significantly correlated with baseline PCVIPR measures of PI and to a lesser extent MF.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101654
Primary Topic
Fatty Acid Research and Health
Type
article
Field-Weighted Citation Impact
0.00
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article

Effects of Icosapent Ethyl, APOE Genotype and CSF Biomarkers on 4D Flow MRI Metrics of Vascular Health in Cognitively Unimpaired Veterans

Carey Elizabeth Gleason, Rachael E. Wilson, Richard J. Chappell, Kate Cronin et al.
Alzheimer s & Dementia
Fatty Acid Research and Health
article

Effects of Icosapent Ethyl, APOE Genotype and CSF Biomarkers on 4D Flow MRI Metrics of Vascular Health in Cognitively Unimpaired Veterans

Carey Elizabeth Gleason, Rachael E. Wilson, Richard J. Chappell, Kate Cronin, Elena Beckman, Allison C Eierman, Cynthia M. Carlsson, Sanjay Asthana, Aleshia Cole, Hannah Zylstra, Emma F Bublitz, Leonardo A. Rivera‐Rivera, Kevin M. Johnson, Sterling C Johnson, Henrik Zetterberg, Carol A. Van Hulle
article en

Abstract

IPE treatment did not significantly impact PCVIPR measures of cerebral blood flow. Baseline vascular CSF biomarker levels, but not APOE ε4 carrier status, significantly correlated with baseline PCVIPR measures of PI and to a lesser extent MF.

Alzheimer s & DementiaVol. 21(S2)
University of Wisconsin System (US), University of Wisconsin–Madison (US), Hong Kong Science and Technology Parks Corporation (HK), William S. Middleton Memorial Veterans Hospital (US), The London College (GB), Wisconsin Division of Public Health (US), University College London (GB), University of Gothenburg (SE)
Good health and well-being
Openalex Percentile: Top 35%
Fatty Acid Research and Health
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