E2814 Mitigates Tau Pathology: Inhibiting Tau Uptake and Promoting MTBR‐Tau Clearance through Microglial Pathways in vitro

Our results suggest that E2814 may slow down pathological spread of tau by directly preventing tau uptake into neurons and accelerating the removal of MTBR-tau via microglial clearance pathway.

Authors

Tatsuo Horizoe
Roberta Tufi (ORCID: https://orcid.org/0000-0001-7295-010X)
Naoki Tokuhara
Yoichi Imaizumi (ORCID: https://orcid.org/0000-0002-8501-9792)
Miki Murota
Malcolm C. Roberts
Hiroshi Ochiai

Institutions

Eisai (United Kingdom) (GB)
Eisai (Japan) (JP)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2025-12-01
DOI: https://doi.org/10.1002/alz70859_102696
Primary Topic: Alzheimer's disease research and treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

E2814 Mitigates Tau Pathology: Inhibiting Tau Uptake and Promoting MTBR‐Tau Clearance through Microglial Pathways in vitro

Tatsuo Horizoe, Roberta Tufi, Naoki Tokuhara, Yoichi Imaizumi et al.

Dec 1, 2025

Alzheimer s & Dementia

Alzheimer's disease research and treatments

article

E2814 Mitigates Tau Pathology: Inhibiting Tau Uptake and Promoting MTBR‐Tau Clearance through Microglial Pathways in vitro

Tatsuo Horizoe, Roberta Tufi, Naoki Tokuhara, Yoichi Imaizumi, Miki Murota, Malcolm C. Roberts, Hiroshi Ochiai

December 1, 2025article en

Abstract

Our results suggest that E2814 may slow down pathological spread of tau by directly preventing tau uptake into neurons and accelerating the removal of MTBR-tau via microglial clearance pathway.

Alzheimer s & DementiaVol. 21(S5)

Eisai (United Kingdom) (GB), Eisai (Japan) (JP)

Openalex Percentile: Top 33%

Alzheimer's disease research and treatments

DOI Open Access PDF OpenAlex

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E2814 Mitigates Tau Pathology: Inhibiting Tau Uptake and Promoting MTBR‐Tau Clearance through Microglial Pathways in vitro — Tatsuo Horizoe, Roberta Tufi, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS