Impact of pTau‐Derived Cognitive Reserve on Alzheimer's Disease Progression

Mean age was 73.7 years, and 42.2% were female. The baseline proportion of dementia patients was higher in the low CR_pTau group compared to the high CR_pTau group. The high CR_pTau group showed slower cognitive decline compared to the low CR_pTau group across all disease stage (p <0.001). The high CR_pTau group showed 45% lower risk of disease stage progression to any stages compared to the low CR_pTau group (p <0.001). Progression of CDR-SB was also slower in the high CR_pTau group and showed 28% lower risk of progression compared to the lower CR_pTau group (p <0.001) CONCLUSION: pTau-derived CR might have impact on disease progression of AD especially.