TOMM40‐G and APOE4 modulate Alzheimer's plasma biomarker levels

The findings suggest that the TOMM40-G risk allele is linked to altered plasma biomarkers. Although further research is needed to clarify sex differences, our results indicate that APOE4 and the TOMM40 rs2075650-G may respectively interact with sex to affect AD biomarkers, underscoring complex sex-specific AD risk.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_099618
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

TOMM40‐G and APOE4 modulate Alzheimer's plasma biomarker levels

Iris Broce‐Diaz, Marcella Barneclo, Judy Pa, Nancy E Ortega
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

TOMM40‐G and APOE4 modulate Alzheimer's plasma biomarker levels

Iris Broce‐Diaz, Marcella Barneclo, Judy Pa, Nancy E Ortega
article en

Abstract

The findings suggest that the TOMM40-G risk allele is linked to altered plasma biomarkers. Although further research is needed to clarify sex differences, our results indicate that APOE4 and the TOMM40 rs2075650-G may respectively interact with sex to affect AD biomarkers, underscoring complex sex-specific AD risk.

Alzheimer s & DementiaVol. 21(S2)
University of California San Diego (US), Alzheimer’s Disease Neuroimaging Initiative (US)
Quality Education
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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TOMM40‐G and APOE4 modulate Alzheimer's plasma biomarker levels — Iris Broce‐Diaz, Marcella Barneclo, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS