Blood Brain Barrier permeability change in clinical stages of Alzheimer disease

We find that increased permeability in specific sub-/cortical GM regions were more prominent in AD dementia than MCI and was significantly different from HC. These changes also linearly tracked severity of cognitive decline. References: 1. Jellinger KA. J Neural Transm (Vienna). 2020; 2. Knopman DS, et al. J Neuropathol Exp Neurol. 2003; 3. Price JL, et al. Neurobiol Aging. 2009; 4. Fiala M, et al. Eur J Clin Invest. 2002; 5. Pillai JA, et al. Ann Clin Transl Neurol. 2019; 6. Sweeney MD, et al. Nat Rev Neurol. 2018; 7. Patlak CS, et al. J Cereb Blood Flow Metab. 1983; 8. Fischl B. Neuroimage. 2012; 9. Montagne A, et al. Neuron. 2015; 10. Nation DA, et al. Nature Medicine. 2019; 11. Sweeney MD, et al. Alzheimers Dement. 2019; 12. van de Haar HJ, et al. Radiology. 2016.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105144
Primary Topic
Barrier Structure and Function Studies
Type
article
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0.00
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article

Blood Brain Barrier permeability change in clinical stages of Alzheimer disease

M. J. Lowe, Jagan A Pillai, James B Leverenz, Wanyong Shin
Alzheimer s & Dementia
Barrier Structure and Function Studies
article

Blood Brain Barrier permeability change in clinical stages of Alzheimer disease

M. J. Lowe, Jagan A Pillai, James B Leverenz, Wanyong Shin
article en

Abstract

We find that increased permeability in specific sub-/cortical GM regions were more prominent in AD dementia than MCI and was significantly different from HC. These changes also linearly tracked severity of cognitive decline. References: 1. Jellinger KA. J Neural Transm (Vienna). 2020; 2. Knopman DS, et al. J Neuropathol Exp Neurol. 2003; 3. Price JL, et al. Neurobiol Aging. 2009; 4. Fiala M, et al. Eur J Clin Invest. 2002; 5. Pillai JA, et al. Ann Clin Transl Neurol. 2019; 6. Sweeney MD, et al. Nat Rev Neurol. 2018; 7. Patlak CS, et al. J Cereb Blood Flow Metab. 1983; 8. Fischl B. Neuroimage. 2012; 9. Montagne A, et al. Neuron. 2015; 10. Nation DA, et al. Nature Medicine. 2019; 11. Sweeney MD, et al. Alzheimers Dement. 2019; 12. van de Haar HJ, et al. Radiology. 2016.

Alzheimer s & DementiaVol. 21(S1)
Cleveland Clinic (US), Lou Ruvo Brain Institute (US)
Openalex Percentile: Top 38%
Barrier Structure and Function Studies
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