The role of Y132‐ in Tyrosine‐Kinase dependent suppression of homomeric Kv1.2: Implications for Alzheimer's Disease
Phosphorylation at site Y132 may be a critical mediator of Aβ based suppression of Kv1.2 current, particularly through endocytotic methods. Suppression of these channels may lead to increased excitotoxicity via increased Ca2+ influx into excitatory neurons and glutamate release.
Authors
- Kristi DeBoeuf
- Joseph Farley
- Dina Jamshidi
- Jack Hyatt
- Logen Yaklin
- Sebastian Burch
Institutions
- Indiana University Bloomington (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107170
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00