Increasing genetic representation globally to advance Alzheimer's disease solutions for all

Our findings confirm the role of APOE e4 in AD risk among African ancestries and its smaller effect size relative to NHW populations, and replicate three additional loci (ABCA7, BCKDK/KAT8, TREML2) that show nominal associations with AD. Admixture and principal component analysis underscores the extensive genetic variability among the African diaspora. Ongoing data collection through the AfDC and READD-ADSP at large to reach 13,000 total participants across global populations will continue to enhance understanding of AD pathogenesis. By leveraging genetic diversity from multiple populations, we can ultimately accelerate the discovery of interventions that benefit all communities.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_106725
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Increasing genetic representation globally to advance Alzheimer's disease solutions for all

Patrice Whitehead, Ndetei Dm, Joshua Odunayo Akinyemi, Mayowa Ogunronbi et al.
Alzheimer s & Dementia
Genetic Associations and Epidemiology
article

Increasing genetic representation globally to advance Alzheimer's disease solutions for all

Patrice Whitehead, Ndetei Dm, Joshua Odunayo Akinyemi, Mayowa Ogunronbi, Blanton Susan, Kazeem Abiodun Akinwande, Reginald Obiako, Albert Kwaku Akpalu, Yared Zenebe Zewde, Pedro Mena, Biniyam Ayele, Raj N Kalaria, OO Baiyewu, Bush Wh, Izri M Martinez, Jenny Chavez, Giuseppe Tosto, Margaret Pericak‐Vance, Samuel Diala, Rufus O. Akinyemi, Katalina F. McInerney, Alzheimer's Disease Sequencing Project (ADSP), Anthony J Griswold, Kara L Hamilton‐Nelson, Fred Stephen Sarfo, Allison M Caban‐Holt, Jonathan L Haines, Kyle M Scott, Christiane Reitz, Andrew F Zaman, Larry D Adams, Farid Rajabli, Michael L Cuccaro, Goldie S Byrd, Adesola Ogunniyi, Brian W Kunkle, Albertino Damasceno, Jeffery M Vance, Kolawole Wahab, Mayowa O Owolabi, Motunrayo Coker
article en

Abstract

Our findings confirm the role of APOE e4 in AD risk among African ancestries and its smaller effect size relative to NHW populations, and replicate three additional loci (ABCA7, BCKDK/KAT8, TREML2) that show nominal associations with AD. Admixture and principal component analysis underscores the extensive genetic variability among the African diaspora. Ongoing data collection through the AfDC and READD-ADSP at large to reach 13,000 total participants across global populations will continue to enhance understanding of AD pathogenesis. By leveraging genetic diversity from multiple populations, we can ultimately accelerate the discovery of interventions that benefit all communities.

Alzheimer s & DementiaVol. 21(S1)
Ahmadu Bello University (NG), University of Ilorin (NG), University of Ghana (GH), University of Miami (US), Eduardo Mondlane University (MZ), University of Ibadan (NG), University of Lagos (NG), Komfo Anokye Teaching Hospital (GH), Ahmadu Bello University Teaching Hospital (NG), Dr. John T. Macdonald Foundation (US), Africa Mental Health Foundation (KE), University School (US), Addis Ababa University (ET), Wake Forest University (US), Case Western Reserve University (US), Columbia University (US), Newcastle University (GB)
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Genetic Associations and Epidemiology
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