Identification of Disease‐Associated Epitopes in Alzheimer's Disease Using Unbiased Antibody Profiling
Our computational approach successfully identifies putative AD-associated epitopes, with a significant overrepresentation of herpesvirus-derived epitopes and CNS autoantigens in AD cases. These findings support a growing body of evidence implicating viral infections and potential autoimmune mechanisms in AD pathology. Further validation and mechanistic studies are warranted to explore the potential role of these epitopes in AD progression.
Authors
- Nathaniel Barton (ORCID: https://orcid.org/0000-0002-0383-7741)
- Michael Jhatro (ORCID: https://orcid.org/0000-0002-6694-9679)
- John Shon (ORCID: https://orcid.org/0000-0001-9465-6286)
- Rebecca L. Best (ORCID: https://orcid.org/0000-0001-7183-879X)
- Elaine T. Lim (ORCID: https://orcid.org/0000-0003-3651-0654)
- Qi Wang (ORCID: https://orcid.org/0000-0002-4016-1939)
- Yingleong Chan
- Diego Mastroeni
- Kathy Kamath
- Benjamin Readhead
Institutions
- Alzheimer's Association (US)
- University of Massachusetts Chan Medical School (US)
- TiGenix (Spain) (ES)
- Institute for Neurodegenerative Disorders (US)
- Banner Sun Health Research Institute (US)
- Arizona Alzheimer’s Consortium
- Arizona State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106171
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00