Mapping Associations Between the Severity of Neuropsychiatric Symptoms and Automatically Extracted Free‐Speech Features
Our exploratory findings indicate that (mainly acoustic) markers derived from free speech are associated with the severity of NPS as measured by clinical scales and with regional brain volumes in participants with NPS. These dual associations highlight the potential of speech analysis as a non-invasive, objective tool to assess NPS in early-stage cognitive decline.
Authors
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Qingyue Li
- Christoph Laske (ORCID: https://orcid.org/0009-0009-3434-936X)
- Luca Kleineidam (ORCID: https://orcid.org/0009-0006-3309-6856)
- Elisa Mallick
- Björn Falkenburger (ORCID: https://orcid.org/0000-0002-2387-526X)
- Zoi Alexopoulou (ORCID: https://orcid.org/0000-0002-1785-1800)
- Melina Stark (ORCID: https://orcid.org/0009-0005-3812-023X)
- Josef Priller
- Inga Zerr
- Jens Wiltfang
- Valeria Manera
- Johannes Tröger
- Frank Jessen
- Stefan J. Teipel
- Michael Wagner
- Emrah Düzel
- Stefanie Köhler
- Alexandra König
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Centre Hospitalier Universitaire de Nice (FR)
- UK Dementia Research Institute (GB)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Cognition Behaviour Technology (FR)
- University Hospital Carl Gustav Carus (DE)
- University College London (GB)
- University of Rostock (DE)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098535
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00