Genetically Induced Mouse Model for Colon-specific Epithelial Cell Tumorigenesis Driven by Loss of K8 and Apc
Genetic colon-specific mouse model with loss of K8 and Apc adequately resembles human CRC. This study identifies anti-tumorigenic protective roles of colonocyte K8 in the colon.
Authors
- Carl-Gustaf A. Stenvall
- Lauri Polari (ORCID: https://orcid.org/0000-0002-0052-6489)
- Mina Tayyab (ORCID: https://orcid.org/0000-0002-5130-7438)
- Mira M.E. Minkkinen
- Diana M. Toivola
- Yatrik M. Shah
- Victor Nielsen
Institutions
- Åbo Akademi University (FI)
- University of Michigan (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101716
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00