Predicting imminent cognitive decline among unimpaired older adults with digital cognitive testing and Alzheimer's disease blood‐based biomarkers
A remote, web-based cognitive assessment of memory consolidation explains unique variance in cognitive decline over approximately 2 years when paired with p-tau217 amongst clinically unimpaired older adults. While p-tau217 alone could predict who might experience cognitive decline, adding an MDLC, which detects deficits related to AD pathology in cognitively normal individuals, further increased the identification accuracy. These results confirm the utility of pairing sensitive digital cognitive assessments with plasma markers to better identify individuals at greatest risk for imminent cognitive decline.
Authors
- Mark A. Dubbelman (ORCID: https://orcid.org/0000-0002-5708-4925)
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Daniel Soberanes (ORCID: https://orcid.org/0000-0001-9099-7294)
- Gad Marshall
- K. N. Johnson
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Lia D'Aquila
- Hyun‐Sik Yang
- Hairin Kim
- Reisa A. Sperling
- Dorene M. Rentz
- Kathryn V Papp
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Mass General Brigham (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103614
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00