Elevated Platelet Aggregation Associates with Increased Alzheimer's Disease Blood Biomarker Concentrations in Patients with Peripheral Artery Disease

Although limited in sample size, our study identified associations of platelet aggregation with markers of AD pathology (p-tau181) and neurodegeneration (NfL) in PAD patients without dementia. Future studies in a larger cohort are needed to further investigate this relationship and the potential role of platelet aggregation as a mediator of AD pathology and neuroinflammatio.