Comparison of the Effect of Chronic Kidney Disease on Plasma <i>p</i> ‐tau217 Determinations versus %p‐tau217 and the <i>p</i> ‐tau217/Aβ42 Ratio in an Amyloid Negative Cohort
The use of either %p-tau217 or the p-tau217/Aβ42 ratio (to a lesser degree) reduced the confounding effects of decreasing eGFR as compared to p-tau217 alone. Aβ42 and Aβ40 exhibited similar reduced predicted increases versus decreasing eGFR as compared to p-tau217. Relative to the predicted effects of decreasing eGFR on p-tau217 measurements, the p-tau217/Aβ42 ratio relative increase was reduced by 40%, while the relative increase was reduced by 63% for %p-tau217 measurements.
Authors
- Jonathan Graff‐Radford
- Stephen D. Weigand (ORCID: https://orcid.org/0000-0002-4541-9011)
- Alicia Algeciras‐Schimnich (ORCID: https://orcid.org/0000-0002-4455-6217)
- Joshua A. Bornhorst (ORCID: https://orcid.org/0009-0003-9297-3271)
- D S Knopman
- Chelsea Swartchick
- Petrice M Cogswell
- Ronald Petersen
- Clifford R. Jack
- Prashanthi Vemuri
- Michael E. Griswold
Institutions
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101203
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00