Synergistic Neuroprotective Effects of a Plant‐Derived Alkaloid and Insulin‐like Growth Factor‐1 on SH‐SY5Y Cells: Targeting the Wnt/β‐Catenin Pathway in Alzheimer's Disease

This study highlights the significant neuroprotective potential of combining a natural alkaloid and IGF-1 against Aβ-induced toxicity, presenting a novel and promising therapeutic strategy for AD. Future research should aim to elucidate the detailed mechanisms underlying these protective effects and confirm their efficacy in in vivo models.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70859_096869
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Synergistic Neuroprotective Effects of a Plant‐Derived Alkaloid and Insulin‐like Growth Factor‐1 on SH‐SY5Y Cells: Targeting the Wnt/β‐Catenin Pathway in Alzheimer's Disease

Prajjwal Sharma
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Synergistic Neuroprotective Effects of a Plant‐Derived Alkaloid and Insulin‐like Growth Factor‐1 on SH‐SY5Y Cells: Targeting the Wnt/β‐Catenin Pathway in Alzheimer's Disease

Prajjwal Sharma
article en

Abstract

This study highlights the significant neuroprotective potential of combining a natural alkaloid and IGF-1 against Aβ-induced toxicity, presenting a novel and promising therapeutic strategy for AD. Future research should aim to elucidate the detailed mechanisms underlying these protective effects and confirm their efficacy in in vivo models.

Alzheimer s & DementiaVol. 21(S5)
Central University of Punjab (IN)
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
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Synergistic Neuroprotective Effects of a Plant‐Derived Alkaloid and Insulin‐like Growth Factor‐1 on SH‐SY5Y Cells: Targeting the Wnt/β‐Catenin Pathway in Alzheimer's Disease — Prajjwal Sharma · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS